This chapter builds upon the presumption that a fusion between entrepreneurship and neuroscience is justified by the methodological and technological advantages facilitated by the former. It first suggests that the joint use of neuroscience tools such as laboratory experiments and brain-driven technologies are propitious to entrepreneurship research because they allow a deeper level of analysis: the entrepreneurial brain. Second, focusing on one of these tools – laboratory experiments – the chapter unveils nine principles to take into account for the good design of an experiment within the structure of a brain-driven entrepreneurship study. It is normal that unraveling these principles are to assist entrepreneurship researchers with gaining a further understanding of the experimental design fundamentals when adopting a neuroscience perspective, while assisting them to moderate the unavoidable challenges ingrained in this interdisciplinary crusade.
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