The contributions of the world's Indigenous Peoples and their Local Communities (IPLCs) counterparts through their knowledge systems are now important pillar in the pursuit of sustainable development. Efforts to ensure that IPLCs are equitably rewarded for their contributions have followed complex regime pathways, ranging from human rights, environmental law, biodiversity conversation, food and agriculture, intellectual property and so on. The concept of access to genetic resources and fair and equitable benefit-sharing (ABS) arising from their utilization by all stakeholders, especially IPLCs, is now the organizing principle around IPLCs rights to their knowledge and innovation in genetic resources. ABS is premised on physical genetic resources and traceability of their provenance in IPLCs. However, synthetic biology, digital sequence information and innovations in the life sciences have reduced genetic resources into dematerialized information. This upends the ABS dynamic, requiring deliberate strategy to secure the rights of IPLCs in the context of genetic resources.
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