Economic growth, in general, is not characterized by a regular and smooth S-shaped curve, but exhibits irregular fluctuations caused by external and internal disturbance factors. The uncertain environment and the wide range of negative effects generated by various global shocks in recent years, forces economies to build their own recovery and shock mitigation mechanisms, especially given that spatial elements are interconnected, and an impairment of the whole can cause more and more fragmentations. This prompts the need for analytical and evidence-based insights into the resilience of countries, regions or cities. In light of these, actionable regional initiatives prove their overwhelming importance in a spatial development process, which is meant to make the connection between decision-makers, places and people. Thereby, this book responds to contemporary challenges associated with critical aspects of resilience and regional development, gathering the contributions of various renowned scholars in spatial planning, urban studies, regional development, geography, and economics.