This chapter presents a framework of scholarly inquiry, highlighting four distinct styles and contributions: theoretical, integrative, craft and clinical. They reflect two fundamental choices that scholars can make in approaching the subject of study: (1) isolating specific aspects of entrepreneurship in search of precision versus merging different viewpoints into a holistic case of entrepreneurial practice; and (2) engaging in descriptive science to establish and relate facts about the world as it is versus engaging in design science to produce instrumental knowledge for enhancing the art and skill of entrepreneurship.