This chapter addresses the African human rights system's response to acts of femicide, such as forced marriage by abduction, political violence against female protesters, and sexual slavery. It considers the Maputo Protocol's response to harmful cultural practices, such as female genital mutilation, and examines the African Commission on Human and Peoples Rights' answer to forced marriage by abduction and political violence in Egyptian Initiative for Personal Rights and Interrights v. Egypt and Equality Now and Ethiopian Women Lawyers Association (EWLA) v. Federal Republic of Ethiopia. The African system's view of human and people's rights can help denote a collectively targeted social group in femicide. The African Commission identifies widespread risks to girls in areas where practices of forced marriages are rampant, without requiring them to report such risks in advance. This understanding of widespread risks is crucial to determine state responsibility for femicide committed by non-state actors.