Across the world enterprise-based activities are seen as important vehicles for addressing a range of social, environmental and economic challenges. Many of these enterprises are considered to be hybrid social enterprises where their business activities support the delivery of their central social and environmental ‘mission’. Countries located in the Global South and emerging economies are seeing an explosion in these types of organisations, often working within the most vulnerable and poorest of communities to address many intractable development challenges. This chapter focuses on the development of a research agenda for such enterprises in these contexts. It begins by introducing some of the specifics of these contexts that potentially differ from developed and Global North contexts. It then introduces some of the overarching macro-level considerations that need to shape this research agenda before presenting some indicative research questions future researchers might like to consider.