Although science studies routinely assume that governance can change research content, we know little about how it does that. This gap in our knowledge is due to a division of labour between science policy studies investigating governance processes and the sociology of science focusing on the construction of scientific knowledge. This chapter bridges the gap by asking how – by what mechanisms and with what effects – research content can be intentionally influenced, and which means of changing research content are available to which actors. I argue that the many governance instruments developed and utilised by actors interested in changing research content have to employ a combination of very few mechanisms for exercising influence. A systematic consideration of these mechanisms and ways in which researchers can respond to their resulting decision situations makes it possible to understand how, and under which circumstances, governance can change research content.