Immigrants’ participation in high-tech industries as both workers and business owners has increased steadily since 2000, at a faster rate than that of their US-born counterparts. Immigrant-owned high-tech businesses are more concentrated in a limited number of industries, such as computer sciences and medical and pharmaceutical-related fields. While the largest immigrant gateways account for a dominant share of all immigrant high-tech entrepreneurs in the country in 2011, new immigrant destinations in the South and West have seen significant increase of immigrants in high-tech industries. For both immigrants and the US-born, a higher number of high-tech businesses is positively associated with regional labor markets that have an overall higher percentage of high-tech industries. At the same time, higher ethnic diversity and a larger share of the foreign-born population are crucial factors in attracting or fostering immigrant high-tech entrepreneurship at the metropolitan level.