Research from several countries indicates that university lecturers and researchers are particularly vulnerable to work-related stress from various sources. This chapter draws on the findings of research conducted by the authors in the UK over several years to highlight the value of a benchmarking approach in monitoring the well-being of academic employees. The literature on the stressors and strains experienced by academics is initially reviewed. The findings of three studies using a well-established framework to assess psychosocial hazards in the university sector in the UK are then presented and discussed. Except for job control, respondents reported lower well-being for each of the seven specified hazards than recommended, with evidence of deterioration over time in some areas. The implications of these findings and the value of supplementing the benchmarking approach with hazards reflecting the current working context are discussed. Priority areas for interventions to enhance well-being among academic employees are identified, and topics for future research proposed.