There are more and more package-related measures (PRMs) developed and adopted for different regulatory purposes. Different PRMs have their respective functions. For food, there are also various kinds of PRMs adopted to address its safety concerns. This chapter will explain the package-related food safety issues. It will also review the relevant TPP rules (including intellectual property, Technical Barrier to Trade (TBT), and investment rules) which are related to the PRMs in a more general manner. The chapter will then focus on the application of these TPP rules to food-related PRMs to see whether they are sufficient in addressing food safety concerns. The chapter is to propose some possible interpretative and legislative approaches to cope with some legislative insufficiencies so as to make the TPP a friendlier agreement for the safety of food.