Using a Chinese sample, the current study investigated work-to-home interference (WHI) in relation to strain and job performance, as well as the moderating effect of Chinese work value (CWV). A total of 513 employees participated in the study. The results showed that WHI was positively related to employees’ physical and psychological strain, while a negative but non-significant relationship was found between WHI and job performance. Further, CWV was found to moderate the above relationships. Specifically, high levels of CWV exacerbated the negative associations between employees’ WHI and their physical and psychological strain. Unexpectedly, for employees with high CWV, job performance was higher when WHI was high compared to when it was low. The results highlight the importance of incorporating culture-specific value constructs when examining the work–home interface.