Destination management is a complex challenge involving knowledge of social economic and environmental attributes and changes which can affect the sustainability of an entire destination and its components. The challenge for tourism managers has always been to make better decisions, ideally based on the information most key to their enterprises and the destinations they inhabit. This article outlines the approaches and activities since the early 1990s to establish a system of indicators for general use by tourism managers and some of the results of this initiative worldwide. It reviews the UNWTO approaches, the development of observatories of sustainable tourism and the relationship between analysis, standards and certification at the destination level. Best procedures to develop indicators and some success stories in application are reviewed.