Within the global market, the research-based pharmaceutical industry engages in a range of well-documented profit-maximising strategies. Key among them is the pursuit of longer and broader monopolies through lobbying for expanded intellectual property (IP) rights, both within individual nation states and via international trade and investment agreements. This chapter traces the attempts of the US pharmaceutical industry to expand IP protections and influence pharmaceutical coverage programs through trade agreements, with a particular focus on the Trans Pacific Partnership Agreement (TPP). Draft texts leaked prior to the conclusion of the negotiations demonstrate the United States’ pursuit of the industry’s interests. The US-based pharmaceutical industry used a number of avenues to influence the negotiations, including representation on trade advisory committees, interaction with trade officials, and intense political lobbying. A range of rhetorical devices and discursive flourishes were employed to persuade policy-makers to adopt the industry’s perspective, while masking its broader strategic objectives. Despite strong public criticism and resistance from other TPP countries, many elements of the US proposals remained in the TPP’s final text, indicating that the industry’s strategies were successful to some degree.