The chapter discusses the spatial aspects of the increased globalization of innovation, analysing both the region’s role in influencing the propensity of actors to engage and to play different roles in global innovation networks (GINs). Until now, different concepts such as global value chain (GVC), global production network (GPN) and GIN have been used to explain the increase globalization of innovation activities. The authors provide a critical overview of these concepts. The involvement of new actors (not just multinationals) from different locations (not just from developed economies) reveal the limitations of frameworks such as GVC and GPN in explaining the structure and dynamics of global networks. The chapter highlights how the concept of GIN, when properly addressed, can lead to a better understanding of the micro and meso dynamics of the new phenomena that arise from the globalization of innovation activities.