It is an inescapable fact that for decades, costly interventions seeking to ‘fix’ Britain’s most disadvantaged communities, where poverty, crime, unemployment and poor health are rife, have largely failed. The ongoing human cost is heart-breaking and the cost to the public purse is immense. The layers of problems presented are undoubtedly complex and appear to be intractable. ‘C2’ (Connecting Communities), makes this very complexity the answer to this challenge. Using a practical seven-step application of complexity science to underpin a delivery framework C2 offers an intervention, delivered on site and in the classroom by a small team of experienced practitioners, working alongside local residents and service providers to enable them to implement the framework. The C2 team is drawn from a range of community leaders, academics and frontline primary healthcare professionals, who have consistently created the conditions for transformative outcomes in many communities across the UK in the last decade, using this approach.