Social businesses are unlikely to emerge without a supportive infrastructure. Nepal Social Business is the first social business incubator to enter the remote district of Jumla in Nepal. Four different social business start-ups were selected for incubation between April 2014 and December 2015. Three of these projects dealt directly or indirectly with malnutrition, which is among the pressing issues of this area. Incubation, when working in regions with a lack of basic infrastructure and entrepreneurs with no formal economic education or relevant business acumen, requires a high degree of personal involvement and relatively more resources, than when working with start-ups in a more developed setting.