In this chapter, the authors discuss entrepreneurship (economic, social, institutional, and environmental) as an often overlooked, yet promising, method to address human-induced climate change. They develop a theoretical framework to enable research into how entrepreneurial action can assist in both mitigating and preventing impacts of climate change. The authors begin by categorizing the causes and impacts of human-induced climate change into: (1) ecological impacts that consist of weather, climate, and environmental implications; (2) societal impacts that comprise both economic issues and population migration; and (3) human health impacts that include physical and psychological symptoms. They then consider the entrepreneurial opportunities embedded within each impact to develop a theory as to when and how entrepreneurs may help mitigate each at the individual, organizational, and industry level. This theory presents a starting point for entrepreneurship research that may help to find solutions to climate change impacts.