The current chapter is the result of the investigation ‘Role and behavior of corporate organizations in the context of sustainability’ and of the reflection of that line of research in the Department of Doctoral Studies of Human and Social and Sustainable Development of the University of Manizales, Colombia. Its construction is part of the analysis of methodologies and processes adapted to different sectors in the field of corporate social responsibility in Colombia. Thus, it addresses many of the themes from the Master’s and Doctoral theses from different citizens and universities in Colombia. It also takes into account many different scientific articles and published documents from Colombian authors. Observed works make use of qualitative, quantitative, mixed, and triangulation methodologies. It was noted that these methodologies are oriented towards the understanding and explanation of principles defined in the areas of government business organizations to cope with the social, economic, and environmental factors, the reconfiguration of values that guide the conduct of corporations, the definition of management and production strategies for the solution of systemic organizational problems, and the redefining of certain corporate practices with the purpose of increasing cohesion and legitimacy between the corporation and society.