This chapter provides a case study on crises and the management of crises by conceptualising and exploring the interconnections between resilience and entrepreneurship. The main focus in this chapter is how politically entrepreneurial strategies might promote resilience in times of crisis. The case study explores the emerging wine sector in Greece as an example of a sector that is resilient despite major economic challenges. Faced by economic challenges due to decreased wine consumption in Greece, many Greek wine producers decided to focus on wine exports and wine tourism. In addition, the crises also triggered collaboration amongst the wine producers through associations and networks to counterbalance EU and national policies that have negatively affected the conditions for wine production. These networks consisted of public and private actors that pooled financial, social and political resources and were able to use European regional development projects for regional development.