This chapter is about State-to-State negotiations in transatlantic trade relations pending ‘secession’ from the EU (Brexit). While it is unclear to what extent the conclusion of a US/UK agreement is compatible with the current policy of ‘America comes first’, negotiations between the two countries could be envisaged before Brexit or during an anticipated transition phase. The formal or implicit empowerment of the UK to negotiate some trade agreements already before Brexit - possibly alongside the EU - could solve some of the problems related to a hard Brexit, at least in regards to strategic trading partners. The EU’s procedures are relatively flexible and can be applied pragmatically. Thus, provided the political will is there, the parties have the tools to prevent or alleviate transitional problems. While this could start before Brexit, it could continue well into a transition period, should there be one.