This chapter proposes an assessment of the various strategies implying the use of mixed methods in comparative politics. In the contemporary literature, methodological pluralism is an important tool to overcome inherited methodological rifts and strengthen the validity of results. The chapter presents the distinctive advantages and limitations of quantitative and qualitative research, discusses various types of mixed-method research and suggests going beyond the distinction between qualitative and quantitative research. A pluralist research method implies specific epistemological assumptions. It is argued that there should be a good fit between methods, their degree of sophistication and their concrete added value. Lastly, this chapter shows how mixed research strategies are able to integrate the understanding and explanatory potential of varied research traditions, and allow researchers to reinforce research designs in comparative politics and to better triangulate, test and validate research results.