In this chapter the authors focus on the environment of SMEs and the national or international political and economic system that enables and supports SMEs in global competition. Therefore, a comprehensive view of SMEs is applied, while the overall information system and its efficient use and management is underlined. The case of Hungarian SMEs is discussed from historic, national, EU and global macroeconomic perspectives. The authors argue that with an increased speed of globalization, there is a need to move towards a more complex view of the SMEs to find the best fitting and most appropriate level of policy intervention and apply fact-based decision processes. The Hungarian case clearly demonstrates that competition and collaboration are simultaneously present on the global market and that only long-term, transparent national policies, along with targeted EU support can contribute to a successful SME recovery and a subsequent dynamic growth. Changing the business culture should include not only the assurance of proper financial support, education and training but also the use of information technology to conduct business (e.g., e-business), furthermore the collection of data, analysis of market data and market information and the generation of timely, accurate knowledge for decision-makers.