Climate change is upon us and, now more than ever, humankind is searching for meaningful solutions to this global problem. However, climate change is a complex situation and intertwined in this grand challenge are the debilitating issues of poverty and environmental degradation in the developing world. Organizations have been part-and-parcel of the problem, yet they hold the solutions as well. Our paper aims to decipher and enhance these solutions through a detailed investigation of the literature and via several case studies of responsibly led organizations that already make a difference in the developing world. We propose a model of how poverty and environmental degradation can be mitigated by pro-environmental-social strategic human resource practices, mediated by responsible leadership. We conclude with a discussion of our findings, explore implications for organizations, suggest future research, and discuss contributions to the transdisciplinary literature.