It is understood that expatriation is a key element of multinational corporations’ (MNCs) strategies for the use of global talent and improving firm performance. What is less clear is how organizations can meet the growing need for talent to expatriate. Lesbian, gay, bisexual, transgender and intersex (LGBTI) employees are often in more senior positions within management in proportion to their heterosexual counterparts, and therefore a significant number of the top 10 per cent of talent often targeted for international assignments. This chapter provides a useful insight into the current research on this topic and how practitioners can best support LGBTI employees.