The social dimension of sustainable development is gaining importance in the sustainability debate. Managing social issues in supply chains improves the economic as well as sustainability performance of the buyers and suppliers. The aim of this chapter is to explain the management of social issues by taking into account the topics that intersect social issues, responsible supply chain actions in relation to corporate social responsibility (CSR), and its impact on the performance outcomes. In doing so, a number of social issues and their related responsible supply chain actions that are required to manage these social issues are identified. Simultaneously, implications on the performance of buyers and suppliers are also elaborated. The identified social issues vary from labour issues to human rights, which affect not only the firms but also society in general. Similarly, to manage the social issues firms adopt responsible supply chain actions ranging from communication and compliance to supply development strategies. A detail account of each of these is provided in this chapter. This chapter contributes to the understanding of managing social issues in supply chains by linking social issues, responsible supply chain actions and performance outcomes. It presents a consolidated view of the research pertaining to the management of social issues in supply chains and provides an overarching conceptual framework.