This chapter discusses theoretical and methodological understandings when undertaking research that explores family interactions in relation to digital media use and issues, and opportunities and constraints for technological engagement, socialization and participation in family life. Specific attention is directed to those studies that explore children’s participation in digital technologies through the theoretical lenses of ethnomethodology and conversation analysis. These approaches examine in fine detail the participants’ moment-by-moment talk and actions (including multimodal actions) as they engage with each other and with digital media. The chapter explores methodological considerations when investigating family interactions in digital media contexts, and briefly discusses the ethical considerations of undertaking research involving children in private and home contexts, and using video-recording data of family interactions with digital media. The chapter concludes with challenges and opportunities for social interaction research that involve family interactions around digital media.