The role of energy as well as the reliability and security of energy networks is increasingly becoming more critical to modern economic and social developments. The global reliance on energy and the interdependence of related infrastructure nationally, regionally and internationally, underscores the implications of conflict, crisis or disaster situations for reliable energy supplies. Generally, energy security comprises the economic and commercial guaranty of demand and supply of energy resources. Equally and increasingly essential is the safeguarding of infrastructure and facilities used for the production and supply of such resources from risks linked to unresolved conflicts, unmitigated crisis or disaster events. The aim of this chapter is to identify and discuss the relationship between conflicts, crises and disasters on the one hand and security of energy supplies globally on the other hand. It focuses on issues relating to the policy and regulatory aspects of safeguarding critical energy (especially oil and gas) infrastructure and supplies by identifying relevant developments in key regions and countries.