Tourism is one of the most economically important industries in Turkey. Istanbul is the most attractive tourist destination in Turkey with historical and cultural heritage and natural beauty. However, stressors and shocks such as political turmoil and economic crises threaten its sustainability. Knowing the risks can lead to the development of strategies for reducing vulnerability and building resilience. This chapter assesses Istanbul’s vulnerability and resilience and presents strategies for building a more resilient tourism industry in Istanbul. The current situation was analysed using SWOT analysis. SWOT analysis facilitates decision-making by determining the internal capabilities and limits (strengths and weaknesses) and external conditions (opportunities and threats) in a given context. SWOT factors were weighted using the analytical_hierarchy process (AHP) method. As a result, six strategies for Istanbul were determined using the TOWS method.