The chapter studies the impact of local and global external knowledge on the innovativeness and productivity of the multinational corporations across the UK. Using the global openness of a firm’s regional industry and its regional economy as proxies for global knowledge flows, the chapter provides new evidence of local and global knowledge spillovers. We find the evidence of positive cluster effects for both strength in the firm’s own industry and the scale and diversity of the industrial base in the firm’s NUTS2 area. We also find that the presence of foreign multinational enterprises (MNEs) in the firm’s line of activity and NUTS2 area has a negative effect on both its patenting and productivity growth. The impact of access to knowledge-intensive professional services is positive for foreign MNEs, except for the high-technology establishments, and positive and significant for the productivity growth in domestic MNEs.