This volume is about how and why entrepreneurs who drive success in the for-profit world become engaged in philanthropy. The topic is both simple and yet profound. It requires an understanding of entrepreneurs in their for-profit world and an understanding of the world of philanthropy. It entails an investigation into the motivations that drive entrepreneurs and philanthropists, and the social and political environments that are conducive to their success. In this brief introduction, we offer some preliminary thoughts on and definitions of entrepreneurship and philanthropy in an effort to establish the parameters of this volume, as both phenomena are difficult to define; definitions, in fact, are the subject of much debate in the scholarly literature for both domains. We also describe our independent interests in this topic and its relationship to previous work, as well as how we came together to collaborate on the project. We close with a brief overview of each of the four sections in the volume.