The Handbook of Inclusive and Social Innovation: The Role of Organizations, Markets and Communities offers a comprehensive review of research on inclusive innovation to address systemic and structural issues – the “Grand Challenges” of our time. With 27 contributions from 57 scholars, the Handbook provides frameworks and insights by summarising current research, and highlights emerging practices and scalable solutions. The contributions highlight a call to action and place social impact at the heart of theory and practice. It will be an invaluable resource for academics, practitioners, and policymakers who champion social inclusion and emphasize innovative approaches to addressing sustainable development goals.